Lack of efficacy of Interferon β-1a in COVID-19 patients with mild to moderate pneumoniaComment Published on 2023-04-012023-07-11 Journal: European journal of internal medicine [Category] COVID19(2023년), [키워드] COVID-19 INFβ-1a Repurposed drugs SARS-CoV-2 type-I interferons. [DOI] 10.1016/j.ejim.2022.11.033 PMC 바로가기 [Article Type] Comment
Corticosteroids: A boon or bane for COVID-19 patients?Article Published on 2022-12-012022-10-27 Journal: Steroids [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] Corticosteroids COVID-19 Glucocorticoids Remdesivir Repurposed drugs [DOI] 10.1016/j.steroids.2022.109102
SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptorsSARS-CoV-2 스파이크 돌연변이는 바이러스 스파이크와 인간 ACE2 수용체 간의 상호 작용을 수정합니다Article Published on 2022-09-102022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding carried complex COVID-19 Effectiveness ENhance feature Health highest human ACE2 receptor Infection interact Interaction interface interface region Interface residues investigated modify molecular molecular interaction mutability Mutation mutations neutralization observé professional Protein question Repurposed drug Repurposed drugs researchers residue SARS-CoV-2 SARS-CoV-2 Spike mutation SARS-CoV-2 virus Scientific community severity significantly spike Spike protein spike protein. spike-ACE2 stability the SARS-CoV-2 virus the Spike Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2022.06.064 PMC 바로가기 [Article Type] Article
In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics transcriptomics. up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
Theaflavin 3-gallate inhibits the main protease (M pro) of SARS-CoV-2 and reduces its count in vitroTheaflavin 3-gallate는 SARS-CoV-2의 주요 프로테아제(M pro)를 억제하고 시험관 내에서 그 수를 감소시킵니다.Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site analysis Anti-viral Atazanavir darunavir demonstrated docking score drug target exhibited flavin gallate in viral in vitro inhibit inhibited inhibitor Interaction isolate Lopinavir M pro Molecular docking study Particle protease Protein reduce reduced reduction Replication Repurposed drug Repurposed drugs residue SARS-CoV-2 SARS-CoV-2 virus target the SARS-CoV-2 virus theaflavin Vero Cell Vero cells Viral particles viral replication viral transcript viral transcripts [DOI] 10.1038/s41598-022-17558-5 PMC 바로가기 [Article Type] Article
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort대규모 용도 변경 노력에서 VERO-E6 세포에 대한 세포변성 SARS-CoV-2 스크리닝Article Published on 2022-07-132022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate anti-inflammatory drug approach Cell Compound COVID-19 COVID-19 disease Dexamethasone Drug discovery drugs effective effort greater highlighting idea identify inhibitor Intensive mechanism Patient patients phenotypic phenotypic screening potential therapies potential therapy reducing mortality Remdesivir repertoire Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection screened shown Support Time to recovery viral infection [DOI] 10.1038/s41597-022-01532-x PMC 바로가기 [Article Type] Article
Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 HelicaseSARS-CoV-2 헬리카제에 대한 약물 및 천연물의 전산 용도 변경으로 인한 잠재적인 COVID-19 치료법Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analgesic anticancer Anticoagulant Antihistamine Antihistamines Antiviral agents antivirals antrafenine applied approach aprepitant AutoDock vina binding energy cabotegravir calculate COVID-19 COVID-19 therapy COVID-19 treatments dicoumarol drug Drug repurposing drugs epirubicin Evidence fexofenadine Helicase in silico in vitro in vivo molecular molecular docking molecular dynamics molecular dynamics. natural non-structural protein nsp13 Potential potential COVID-19 treatments product Protein reported Repurposed drug Repurposed drugs repurposing RSV-604 SARS-CoV-2 Screen tandem the SARS-CoV-2 Treatment Virtual screening [DOI] 10.3390/ijms23147704 PMC 바로가기 [Article Type] Article
Mechanistic insights of key host proteins and potential repurposed inhibitors regulating SARS-CoV-2 pathwaySARS-CoV-2 경로를 조절하는 주요 숙주 단백질 및 잠재적 용도 변경 억제제에 대한 기계론적 통찰력Article Published on 2022-07-052022-09-11 Journal: Journal of computational chemistry [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome camostat catalytic activity Clinical studies clinical study develop dissociation pathways drug drugs Efficacy eIF4E2 energetics finding HDAC2 Host host protein host proteins independent inhibitor inhibitors inhibitory involved Keeping Kinetics mechanism mechanisms Metadynamics molecular molecular dynamics molecular dynamics. MOST nafamostat pandemic paper pathway Pathways Patient Probability Protein Repurposed drugs residue residues SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 patients Silmitasertib Support target targets treat Vaccine Valproic acid variant Zotatifin [DOI] 10.1002/jcc.26888 PMC 바로가기 [Article Type] Article
Remdesivir and Its Combination With Repurposed Drugs as COVID-19 TherapeuticsReview Published on 2022-05-122023-07-02 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, [키워드] Baricitinib COVID-19 Remdesivir Repurposed drugs Therapeutics [DOI] 10.3389/fimmu.2022.830990 PMC 바로가기 [Article Type] Review
Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature’s toolbox of bioactive compoundsReview article Published on 2022-03-142022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] approved drug assays binding affinity candidate clinical trials Compound compounds consequence coronavirus Coronaviruses drug effective Enzyme inhibition Extracts in silico in vitro in vivo Infection inhibiting inhibition inhibitor inhibitors inhibitory involved main protease MPro mutations natural compounds Outbreaks pandemic protease protease active site Repurposed drugs Research respiratory SARS-CoV-2 shown vaccination viral life cycle viral replication virus [DOI] 10.1016/j.csbj.2022.03.009 [Article Type] Review article